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Prof. Bernard C. Rossier

Ms Marie-Madeleine
+41 22 704 36 41

Webmaster: morard@jeantet.ch

Chemin Rieu 17
P.O. Box 270
1211 Geneva 17
+41 22 704 36 36
+41 22 704 36 37


Jorge E. Galán

Yale University School of Medicine, New Haven (USA)

Department of Microbial Pathogenesis

Tuesday, October 23, 17:00 - 17:30

Interaction of Salmonella with host cells: type III secretion in action

One of the most exciting developments in the field of bacterial pathogenesis during the last two decades has been the discovery that bacterial pathogens utilize specialized nanomachines to deliver bacterial proteins into eukaryotic cells. These proteins have the capacity to modulate a variety of cellular functions for the pathogen’s benefit. This strategy is widespread in nature since the presence of this type of machines has been detected in many bacteria pathogenic or symbiotic for animals, plants, or insects. One of this type of machines is known as the Type III Secretion System. The bacterial pathogen Salmonella enterica encodes two of these machines, which deliver a battery of more than 50 proteins known as "effectors". The coordinated activity of these effectors allows Salmonella to enter into host cells, avoid innate immune responses and build an intracellular niche suitable for its replication.

I will discuss the activity of several of these effectors as well as their role in bacterial virulence.  



Jorge E. Galán is a graduate of National University of La Plata, Argentina, where he completed his Veterinary Science degree in 1982.  He earned his PhD at Cornell University in Molecular Biology in 1986 and completed his postdoctoral studies at Washington University in St. Louis.  Before coming to Yale in 1998, he was an Associate Professor at SUNY Stony Brook, within the Department of Molecular Genetics and Microbiology. Currently, he is the Lucille B. Markey Professor of Microbiology, Chair of the Department of Microbial Pathogenesis at the Yale University School of Medicine. 

Jorge E. Galán’s laboratory specializes in molecular mechanisms of bacterial pathogenesis, primarily focusing on the mechanisms by which the bacterial pathogens Salmonella and Campylobacter interact with host cells to cause disease.

Jorge E. Galán is the recipient of numerous honors and awards including the Pew Scholar in Biomedical Sciences in 1990, the Searle Scholar Award in 1991, the National Institutes of Health MERIT Award in 2000, the Hans Sigrist Prize in 2002, the Alexander M. Cruickshank Award in 2010, and the Robert Koch Prize in 2011. He is a member of the American Academy of Microbiology, the German Academy of Sciences Leopoldina, and a fellow of the American Association for the Advancement of Sciences. He is a member of several Scientific Advisory Boards and has authored more than 160 publications in the field of bacterial pathogenesis and molecular biology.