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Prof. Bernard C. Rossier
rossier@jeantet.ch

Secretariat:
Ms Marie-Madeleine
Cuenat
+41 22 704 36 41
cuenat@jeantet.ch

Webmaster: morard@jeantet.ch

Louis-Jeantet
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Chemin Rieu 17
P.O. Box 270
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Switerland
Phone
+41 22 704 36 36
Fax
+41 22 704 36 37


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Kun-Liang Guan

University of California, San Diego (USA)

Department of Pharmacology, Moores Cancer Center

Wednesday, October 24, 09:00 - 09:30

The TOR pathway in cell growth and autophagy

The mammalian Target Of Rapamycin (mTOR) is a central cell growth controller that is regulated by nutrient status.  High mTOR activity promotes anabolism and protein translation. In contrast, low mTOR activity inhibits growth and initiates autophagy. We have observed that the AMP activated protein kinase (AMPK) and mTOR play a major role in relaying nutrient signals to autophagy regulation.  Both AMPK and mTOR directly modulate the autophagy mechanism by direct phosphorylation, therefore protect cells from nutrient stress conditions.

Biography

Kun-Liang Guan: B.S. (1982) Hangzhou University, China; Ph.D. (1989) Purdue University; Assistant Professor to Professor (1992-2007), University of Michigan; Halvor Christensen Professor (2003-2007), University of Michigan; Professor (2007-present), University of California, San Diego; MacArthur Fellow (1998), the John D. & Catherine T. MacArthur Foundation; Scherling-Plaugh Award (1999), American Society of Biochemistry and Molecular Biology; Faculty Recognition Award (2004), University of Michigan; Distinguished Alumni Award (2006), Purdue University; Elected Fellow of AAAS (American Association for the Advancement of Science) (2011).

Research: interested in signal transduction and cancer cell biology with more than 200 scientific publications.

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