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JÖrg Vogel

University of Würzburg (Germany)

IMIB - Institute for Molecular Infection Biology

Tuesday, October 23, 15:30 - 16:00

Small RNAs in bacterial pathogens

This talk will discuss emerging concepts of gene regulation by small noncoding RNAs in pathogenic bacteria. I will present examples of how RNA deep sequencing technology has opened new avenues for the global discovery and functional study of diverse functional small RNAs in many bacterial species. Furthermore, I will discuss recent work to reveal how small RNAs and the RNA-binding protein Hfq cross-wire the core genome and horizontally acquired virulence regions of Salmonella at the post-transcriptional level, including their roles in regulating the production of secreted virulence factors.

Selected accompanying papers 

Papenfort K. et al. (2012)

The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair

PNAS 109(13):E757-64

Kröger C. et al. (2012)

The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium

PNAS in press

Vogel J. & Luisi B.F. (2011)

Hfq and its constellation of RNA

Nature Reviews Microbiology 9(8):578-89

Deltcheva E. et al. (2011)

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

Nature 471(7340):602-7

Sharma C.M. et al. (2010)

The primary transcriptome of the major human pathogen Helicobacter pylori

Nature 464(7286):250-5

 

Biography

Jörg Vogel has been Professor and Chair of the Institute for Molecular Infection Biology at the University of Würzburg, Germany, since 2009. His main interests are regulatory small RNAs in pathogenic bacteria, and infection-associated microRNAs and long noncoding RNAs in eukaryotic hosts. Having studied biochemistry in Berlin and London, he graduated from Humboldt University Berlin with work on catalytic introns (1999). Following postdoctoral research on small RNA discovery at Uppsala University and Hebrew University Jerusalem, he became group leader position for RNA Biology at the Max-Planck Institute for Infection Biology in Berlin (2004–2009). He was elected EMBO member in 2011.

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