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For further information,
please contact:

Carol Cheneval
Coordination Symposium
T: +41 22 704 36 31
F: +41 22 704 36 37
cheneval@jeantet.ch





Louis-Jeantet
Foundation (LJF)

Chemin Rieu 17
P.O. Box 270
1211 Geneva 17
Switzerland
T: +41 22 704 36 36
F: +41 22 704 36 37
info@jeantet.ch


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Taija Makinen

University of Uppsala

Wednesday, October 23, 15:50 - 16:15

Organ-specific mechanisms of lymphatic development

The lymphatic system is composed of a hierarchy of vessels with specific features serving their unique functions: the blind-ended lymphatic capillaries that absorb the interstitial fluid and the collecting lymphatic vessels that transport the lymph to the cardiovascular system. Failure of the lymphatic vessels, caused by a genetic defect (primary) or damage following surgery or radiation therapy (secondary) can lead to lymphoedema and contribute to pathogenesis of obesity, atherosclerosis and cardiovascular disease. Lymphoedema is a progressive and lifelong condition characterised by gross swelling of the affected tissue. Notably, several primary lymphoedemas are characterised by defects that affect specifically either the collecting vessels or the capillaries. In addition, specific area(s) of the body are affected in different types of lymphoedemas. Molecular mechanisms underlying organ- and vessel-type specific manifestation of lymphatic dysfunction are poorly understood yet this knowledge is instrumental in designing therapeutic strategies for lymphoedema and other lymphatic disorders that are currently lacking. In this lecture I will discuss our new findings that reveal organ-specific mechanisms required for the formation of a functional lymphatic vascular network and provide insight into pathophysiological mechanisms involved in lymphoedema.

Biography

Taija Makinen obtained her PhD in Prof. Kari Alitalo’s laboratory at the University of Helsinki. After post-doctoral training in Prof. Rudiger Klein’s laboratory at the Max-Planck-Institute of Neurobiology in Martinsried, she moved to London to establish her research group at the Cancer Research UK London Research Institute. In 2013 she moved to Rudbeck Laboratory at the Uppsala University, where her laboratory continues to study the mechanisms of lymphatic vascular development.

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