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Carol Cheneval
Coordination Symposium
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F: +41 22 704 36 37

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T: +41 22 704 36 36
F: +41 22 704 36 37


Tatiana Petrova

University of Lausanne

Wednesday, October 23, 16:15 – 16:40

Biomechanical and transcriptional regulation of lymphatic vascular development

Vertebrates have two vascular systems, both of which are indispensable for life: blood vessels, which bring oxygen and nutrients to the tissues, and lymphatic vessels, which remove proteins and excess of fluid from the interstitial space and return them back to the blood circulation. Lymphatic vessels are also important regulators of the immune response, as they transport peripheral antigens to lymph nodes.

The directional flow of lymph is maintained by intraluminal lymphatic valves. Lymphatic valves are therefore crucial to prevent lymphedema, accumulation of fluid in the tissues; yet, the mechanisms of valve formation are not fully understood. In addition, the role of flow in lymphatic vascular development is only beginning to be appreciated. We use a combination of the in vivo genetic approaches and in vitro studies of mechanotransduction to establish the hierarchy of molecular events in lymphatic valve morphogenesis and vascular patterning. We aim to uncover novel pathways implicated in the regulation of endothelial mechanotransduction and to study their role in developmental and pathological remodeling of lymphatic vessels.


Tatiana Petrova received her M.Sc in chemistry from Moscow State University and a Ph.D. in biochemistry from the University of Geneva. She did a post-doctoral work at Northwestern University in Chicago, and then moved to a second postdoctoral position at the University of Helsinki, Finland. In 2004 she became a group leader at Molecular Cancer Biology Program at the University of Helsinki, and in 2008 joined CHUV and University of Lausanne as an SNF professor. Her main research interests are the molecular mechanisms of vascular growth and remodeling.