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please contact:

Carol Cheneval
Coordination Symposium
T: +41 22 704 36 31
F: +41 22 704 36 37
cheneval@jeantet.ch





Louis-Jeantet
Foundation (LJF)

Chemin Rieu 17
P.O. Box 270
1211 Geneva 17
Switzerland
T: +41 22 704 36 36
F: +41 22 704 36 37
info@jeantet.ch


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Peter J. Ratcliffe

University of Oxford

Chairmen

Keynote Lecture: Understanding cellular oxygen sensing pathways; what are the implications?

Work on oxygen sensing pathways regulating the erythropoietin gene unexpectedly revealed the existence of a widespread system of gene regulation by oxygen, which is tightly conserved throughout the animal kingdom. Analysis of this system revealed an unprecedented signalling process, based on the post translational hydroxylation of the key transcription factor HIF, by a series of 2-oxoglutarate-dependent dioxygenases. The presentation will review the biochemical, physiological, pathological, and therapeutic challenges arising from this work..

Biography

Professor Peter Ratcliffe trained in medicine at Gonville and Caius College, Cambridge and St. Batholomew’s Hospital, London. He trained as a nephrologist before founding the Hypoxia Biology Laboratory at Oxford, with support from the Wellcome Trust. He is currently the Nuffield Professor of Clinical Medicine and Head of the Nuffield Department of Clinical Medicine at the University of Oxford.

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