The 2015 Louis-Jeantet Prize for medicine is awarded to Emmanuelle Charpentier, Head of the Department Regulation in Infection Biology at the Helmholtz Centre for Infection Research in Braunschweig, Germany and Guest Professor at the Laboratory for Molecular Infection Medicine, Umeå University, Sweden, and to Rudolf Zechner, Professor of Biochemistry, Institute of Molecular Biosciences, University of Graz, Austria.